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Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT
This study compared the effects of probiotics versus autologous fecal microbiome transplantation (aFMT) on gut microbiome recovery after antibiotic use in mice and humans. Probiotics delayed gut microbiome and gene expression recovery, while aFMT resulted in a rapid and near-complete recovery. These findings suggest that probiotics may hinder post-antibiotic gut recovery, highlighting the need for alternative approaches like aFMT or personalized probiotics.
Graphical abstract from Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.
Key Takeaways
Probiotics delay native microbiome recovery post‑antibiotics.
Contrary to common belief, administering probiotics after a course of antibiotics slows down the return of the gut's native microbial community to its pre-antibiotic state.
Figure S3 (B) Stool alpha diversity. ∗p < 0.05; ∗∗∗p < 0.001, Two-Way ANOVA & Tukey between spontaneous recovery and probiotics.
FMT restores microbiome fastest post-antibiotics.
In contrast to probiotics, using fecal microbiota transplantation (FMT) rapidly reinstates the native microbial composition and functions, outperforming both probiotic and no-intervention groups .
Figure S3 (G) Alpha diversity in tissues of the UGI, significance according to Kruskal-Wallis & Dunn’s.
Probiotics expand the antibiotic resistance gene pool.
Probiotics increased the diversity and abundance of antibiotic resistance genes in the mucosal microbiome, where bacteria are more likely to exchange genetic material with the host and other microbes.
Citation
Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., Horn, M., Cohen, Y., Moor, A. E., Zeevi, D., Korem, T., Kotler, E., Harmelin, A., Itzkovitz, S., Maharshak, N., … Elinav, E. (2018). Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous fmt. Cell, 174(6). https://doi.org/10.1016/j.cell.2018.08.047
