Relieve the Microbiome

It can be challenging to provide immediate relief to patients suffering from gastrointestinal symptoms, and even more so when the cause of their clinical signs is unknown. While it has been an acceptable practice to default to prescribing antibiotics, especially in cases of acute diarrhea, there is now a way to effectively manage clinical symptoms quickly without harming their gut microbiome.

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When Relief Kits Are A Good Choice

Our Relief Kits can be used as a stand-alone therapy, but can also be used concomitantly with other treatments to support patient health.

Top GI Relief Kit Use Cases:

  • Acute GI cases
  • Chronic enteropathy cases
  • Food trials
  • Diet transitions
  • Antibiotic-associated diarrhea
  • Dietary indiscretions
  • Acute hemorrhagic diarrhea syndrome (HGE)

Top Skin & Coat Use Cases:

  • Atopic dermatitis
  • Malassezia dermatitis
  • Seasonal allergies
  • Non-ectoparasitic pruritic conditions
  • Dermatophytosis

How Relief Kits Work

Our Relief Kits leverage the latest advancements in microbiome science to combat acute clinical signs of microbiome-associated conditions. Our Relief Kits include a 15-day supply of our Gut Restore Supplement (FMT capsules) and the appropriate Relief supplement, GI Relief or Skin & Coat Relief.

GI Relief Kits

The GI Relief supplement’s cocktail includes prebiotics, bacteriophages, and probiotics helps reduce symptoms within 24-48 hours. The Gut Restoration Supplement begins the microbiome restorative process and protects against future dysbiosis.

Skin and Coat Relief Kits

The Skin & Coat Relief supplement’s cocktail includes postbiotics, omega fatty acids, and other evidence-based ingredients to reduce dermatological symptoms within 24-48 hours. The Gut Restoration Supplement begins the microbiome restorative process and protects against future dysbiosis.

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Microbiome-Friendly Solutions

Prebiotics

Prebiotics, such as fructooligosaccharides (FOS), are effective at reducing both gastrointestinal and dermatological symptoms. In many cases of atopic dermatitis and acute diarrhea, the body is in a hyper-inflammatory state. Prebiotics are able to support beneficial bacteria, bind to pathogens, and activate the immune system to control inflammation.1–5 FOS is an ingredient included in our GI Relief Kits.

Bacteriophages

Beneficial bacteria struggle in inflamed environments, while pathogens can flourish. For example, E. coli feeds on the excess mucosal production produced when the gut is in an inflamed state. Further E. coli growth can trigger more inflammation, and a vicious cycle ensues.

Findings from our State of the Gut report show that one in seven cats and one in three dogs have elevated levels of E. coli. It is the most common bacteria behind diarrhea cases in both cats and dogs. Research shows that antibiotics are not an effective solution to high-E. coli cases.7–9 

Bacteriophages, like PreforPro, an ingredient in our Relief Kits, are viruses that specifically target and kill specific bacteria like E. coli. Therefore, E. coli specific bacteriophages reduce pathogenic E. coli counts, leaving the mammalian and other bacteria cells unharmed, breaking the cycle of inflammation. This alleviates hyper-inflammatory symptoms including diarrhea.

Probiotics

The probiotic Saccharomyces boulardii is established in scientific literature to be effective at preventing antibiotic-associated diarrhea, improving symptoms of acute diarrhea, treating Clostridium perfringens infections, treating Clostridioides difficile infections, among other applications.10–15 As an ingredient in our GI Relief Kits, Saccharomyces boulardii can help relieve a range of common causes of acute GI clinical signs.

Additionally, being a yeast and not a bacteria probiotic, S. boulardii functions well in feline and canine intestinal tracts and is not affected by antibiotic use.

Postbiotics

Postbiotics are the metabolic byproducts from beneficial bacteria. A growing body of research highlights a wide array of health benefits of probiotics, including supporting the immune system, preventing disease, improving gut health, and reducing inflammation.16–18 Postbiotics are naturally produced in the gut during microbial fermentation of fiber, but supplemental postbiotics can help improve gut health when additional dietary fiber is not feasible and the efficacy of certain probiotics.18 Our Skin & Coat Relief kit includes EpiCor, a postbiotic from Saccharomyces cerevisiae fermentate.

Gut Restore Supplement (Fecal Microbiota Transplant)

Dysbiosis of the gut microbiome is associated with recurring clinical signs of many chronic gastrointestinal, dermatological, and immune-related conditions. Unlike common treatments that only target symptom relief, Fecal Microbiota Transplants (FMTs) can resolve the root cause of your patient’s condition. FMTs provide a healthy and balanced community of microbes, and contain important molecules necessary for effective immune modulation.19

FMTs introduce species-specific microbes that can begin normal functions, restore balance, and produce beneficial metabolites in the recipient. The diverse and balanced community of microbes from an FMT can compete with pathogenic bacteria for space and food . With approximately 70% of immune cells found in the intestinal tract, the actions of the bacteria in FMTs can break the cycle of inflammation that may be contributing to your patient’s acute symptoms.20

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Citations

  1. Pujari R, Banerjee G. Impact of prebiotics on immune response: from the bench to the clinic. Immunol Cell Biol. 2021;99(3):255-273. doi.org/10.1111/imcb.12409 
  2. Van Hul M, Karnik K, Canene-Adams K, De Souza M, Van den Abbeele P, Marzorati M, et al. Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation, and gut microbiome of high-fat diet-fed mice. Am J Physiol Endocrinol Metab. 2020;319(4):E779-E791. doi.org/10.1152/ajpendo.00108.2020 
  3. Al-Ghazzewi FH, Tester RF. Impact of prebiotics and probiotics on skin health. Benef Microbes. 2014;5(2):99-107. doi.org/10.3920/BM2013.0040 
  4. Swanson KS, Grieshop CM, Flickinger EA, Bauer LL, Healy HP, Dawson KA, et al. Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs. J Nutr. 2002;132(5):980-989. doi.org/10.1093/jn/132.5.980 
  5. Pengrattanachot N, Thongnak L, Lungkaphin A. The impact of prebiotic fructooligosaccharides on gut dysbiosis and inflammation in obesity and diabetes related kidney disease. Food Funct. 2022;13(11):5925-5945. doi.org/10.1039/D1FO04428A 
  6. Conway T, Cohen PS. Commensal and Pathogenic Escherichia coli Metabolism in the Gut. Microbiology spectrum. 2015;3(3). doi:10.1128/microbiolspec.MBP-0006-2014
  7. Gutiérrez B, Domingo-Calap P. Phage Therapy in Gastrointestinal Diseases. Microorganisms. 2020;8(9). doi:10.3390/microorganisms8091420
  8. Lin DM, Koskella B, Lin HC. Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. World J Gastrointest Pharmacol Ther. 2017;8(3):162-173. doi.org/10.4292%2Fwjgpt.v8.i3.162 
  9. Smith HW, Huggins MB. Successful treatment of experimental Escherichia coli infections in mice using phage: its general superiority over antibiotics. J Gen Microbiol. 1982;128(2):307-318. doi.org/10.1099/00221287-128-2-307 
  10. Czerucka D, Piche T, Rampal P. Review article: yeast as probiotics -Saccharomyces boulardii. Alimentary Pharmacology & Therapeutics. 2007;26(6):767-778. doi:10.1111/j.1365-2036.2007.03442.x
  11. Moré MI, Swidsinski A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – a review. Clinical and Experimental Gastroenterology. Published online 2015:237. doi:10.2147/ceg.s85574
  12. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801. doi.org/10.1111/apt.13344 
  13. Ehrhardt S, Guo N, Hinz R, Schoppen S, May J, Reiser M, et al. Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Open Forum Infect Dis. 2016;3(1):ofw011. doi.org/10.1093/ofid/ofw011 
  14. Tariq R, Yadav D, Tahir MW, Sehgal K, Pardi D, Khanna S. S136 Efficacy of Saccharomyces boulardii for Prevention of Clostridioides difficile Infection: A Systematic Review and Meta-Analysis. Official journal of the American College of Gastroenterology | ACG. 2021;116:S59. doi.org/10.14309/01.ajg.0000773016.43460.eb 
  15. Golić N, Veljović K, Popović N, Djokić J, Strahinić I, Mrvaljević I, et al. In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens. BMC Microbiol. 2017;17(1):108. doi.org/10.1186/s12866-017-1015-5 
  16. Zhang T, Zhang W, Feng C, Kwok LY, He Q, Sun Z. Author Correction: Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model. NPJ Sci Food. 2023;7(1):4. doi.org/10.1038/s41538-023-00179-1 
  17. Sadeghi A, Ebrahimi M, Kharazmi MS, Jafari SM. Effects of microbial-derived biotics (meta/pharma/post-biotics) on the modulation of gut microbiome and metabolome; general aspects and emerging trends. Food Chem. 2023;411:135478. doi.org/10.1016/j.foodchem.2023.135478 
  18. Li HY, Zhou DD, Gan RY, Huang SY, Zhao CN, Shang A, et al. Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review. Nutrients. 2021;13(9). doi:10.3390/nu13093211
  19. Ademe M. Benefits of fecal microbiota transplantation: A comprehensive review. J Infect Dev Ctries. 2020;14(10):1074-1080. doi.org/10.3855/jidc.12780 
  20. Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021;13(3). doi:10.3390/nu13030886

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