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The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats
Dr. Jamie Anderson, DVM, MS, DAVDC, DAVCIM, explains microbiome terminology, the microbiome composition in various oral cavity areas in healthy cats and those with oral disease, and the testing methods used in a recent study. More info: https://pubmed.ncbi.nlm.nih.gov/38003162/.
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Browse Supporting Research
Oral Fecal Microbiota Transplantation in Dogs with Tylosin-Responsive Enteropathy—A Proof-of-Concept Study
Hanifeh et al. (2024). Veterinary Sciences.
This clinical trial evaluated the impact of fecal microbiota transplantation (FMT) on dogs with tylosin-responsive enteropathy (TRE), focusing on clinical symptoms, fecal consistency, and microbiome composition. The trial had four phases, including screening, re-introduction of tylosin, treatment with FMT or placebo, and a follow-up. Both FMT and placebo groups showed improved microbiome diversity after treatment. On average, 30.4% of donor bacterial strains engrafted in FMT recipients.
Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms
Tuniyazi M, Hu X, Fu Y, Zhang N. (2022) Vet Sci.
Fecal microbiota transplantation (FMT) is a promising new therapy for dogs with gastrointestinal issues. However, safety concerns and a lack of understanding of its mechanisms limit its wider use. This paper reviews the current applications and efficacy of canine FMT, explores its potential mechanisms, and discusses future directions for research, including donor selection, recipient preparation, administration routes, stool storage, and potential applications beyond gastrointestinal disorders.
Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues
Rojas et al (2023). Veterinary Sciences.
This study explores the effects of fecal microbiota transplants (FMTs) in domestic cats with chronic digestive issues using oral capsules containing lyophilized stool. Changes in bacterial composition, including shifts in Clostridium, Collinsella, and Escherichia, were observed post-FMT, as well as donors sharing 13% of their bacterial variants with recipientsThe study suggests that FMT outcomes are influenced by the recipient's symptoms, diet, and donor microbiome.
Clinical Guidelines for Fecal Microbiota Transplantation in Companion Animals
Winston, Jenessa A. et al. (2024). Advances in Small Animal Care.
The Companion Animal FMT Consortium aims to increase accessibility of FMT as a microbial-directed therapeutic for dogs and cats by simplifying and demystifying the process of performing FMT in clinical practice. These FMT clinical guidelines are intended for veterinarians in a variety of clinical practice types and can be modified and adapted as needed to align with financial and technical resources available to individual practitioners.
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